反应详情

To 6.02 g of desipramine hydrochloride was added 150 ml of 1N NaOH. The mixture was allowed to stir for 10 minutes. The aqueous mixture was extracted with 6×100 ml of chloroform. The combined chloroform layer was washed with 200 ml of water. The organic part was dried (Na2SO4) and concentrated to give 5.25 g of desipramine free base.

1. extractionThe aqueous mixture was extracted with 6×100 ml of chloroform
2. washThe combined chloroform layer was washed with 200 ml of water
3. dry with materialThe organic part was dried (Na2SO4)
4. concentrationconcentrated