Hydrazine hydrate (1:1) → HCID 70104763, compound

Participants

Reaction Conditions

Reaction Steps

6-(2-Methylpyridin-3-yloxy)-pyridazine-3-carboxylic acid ethyl ester (D11) (1.07 g, 4.13 mmol) and hydrazine monohydrate (0.23 ml, 7.22 mmol) in ethanol (100 ml) was stirred at room temperature for 1 hour then heated at 50° C. for 1 hour and finally heated at reflux for 4 hours. A second portion of hydrazine monohydrate (0.23 ml, 7.22 mmol) was added and the mixture refluxed for a further 2 hours. After being allowed to cool the solvent was removed in vacuo. The off-white solid residue was subjected to column chromatography using 25% MeOH/EtOAc as eluant, resulting in a white crystalline product (0.63 g, 62%).

Provenance & Evidence