Nitric Acid → HCID 18717653, compound

HRID 840559Notes

Reaction equation

HRID 840559 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([Cl:21])[CH:19]=2)[NH:14][C:13](=[O:22])[C@@H:12]1[CH3:23])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:24]([O-])([OH:26])=[O:25]>C(O)(=O)C>[CH2:1]([O:8][C:9]([N:11]1[C:20]2[C:15](=[C:16]([N+:24]([O-:26])=[O:25])[CH:17]=[C:18]([Cl:21])[CH:19]=2)[NH:14][C:13](=[O:22])[C@@H:12]1[CH3:23])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 18717652HCID 18717652, compound

Product 1

HCID 18717653HCID 18717653, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The compound of Example III (1.5 g, 4.5 mmol) was nitrated in glacial acetic acid (15 ml). A total of 5 ml (124.3 mmol) of fuming nitric acid were added dropwise in the course of 4 hours at 0° C. to room temperature. The mixture was subsequently poured into 100 ml of ice-water, and the product, which was obtained in the form of a yellow solid, was filtered off, washed thoroughly with water, and dried. Melting point 85° C. (subl.).

Workup

  1. customthe product, which was obtained in the form of a yellow solid
  2. filtrationwas filtered off
  3. washwashed thoroughly with water
  4. customdried

Sources & evidence

ORD record
ord-ca5969991194442ea4c3bf67e1a7a060
Source dataset
uspto-grants-2002_04
Patent number
US06369057B1

Reaction notes

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