HCID 18717653, compound → HCID 70012865, compound

Participants

Reaction Steps

The compound of Example IV (1.5 g, 4.0 mmol) was dissolved in 150 ml of methanol and hydrogenated at room temperature with Raney nickel catalysis, using 1 atm hydrogen. When the calculated amount of hydrogen had been taken up, the catalyst was removed by filtration with suction, and the filtrate was concentrated in vacuo. The product was purified by silica gel chromatography using ethyl acetate/heptane=2:1 as eluent. The yield was 0.68 g (49%) of brownish solid of melting point 152-154° C.

Provenance & Evidence