Triethylamine → HCID 86757927, compound

Participants

Reaction Steps

3-Nitrobenzylamine (511 mg, 2.71 mmol) and 3-(2-chloro-6-fluorophenyl)-5-methylisoxaz-4-oyl chloride (742 mg, 2.71 mmol) were suspended in 10 mL of dichloromethane and triethylamine was added (0.95 mL, 6.78 mmol). The reaction went clear and was stirred at room temperature for 2 hours. The reaction was then diluted with 100 mL of ethyl acetate and the organic layer was washed twice each with 1N aqueous hydrochloric acid and 1N aqueous sodium hydroxide. The organic layer was then dried over sodium sulfate, filtered, and concentrated in vacuo to give 1.12 g of the title compound. (>100). MS(IE) m/z 390 (M+1). IR 3280, 1648, 1532, 1349, 1251 cm−1.

Provenance & Evidence