HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-methyl 2-hydroxy-3-phenylpropanoate → (2R)-2-[4'-(2-Benzyl-benzo[b]thiophene-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-3-phenyl-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-methyl 2-hydroxy-3-phenylpropanoate | HCID 5289077 | — |
| Reactant | 4'-(2-Benzyl-benzo[b]thiophen-3-yl)-3,5-dibromo-biphenyl-4-ol | HCID 10721373 | — |
| Product | (2R)-2-[4'-(2-Benzyl-benzo[b]thiophene-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-3-phenyl-propionic acid | HCID 9810271 | — |
Reaction Steps
The title compound was prepared from 4′-(2-benzyl-benzo[b]thiophen-3-yl)-3,5-dibromo-biphenyl-4-ol, and (S)-(−)-3-phenyllactic acid methyl ester, in substantially the same manner, as described in Example 1, steps g-h, and was obtained as a white solid, mp 87-89° C.; MS m/e 696 (M+);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06369072B2 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-0590ed4abb544b5aa4391eb6649091b4 |
| Source note | uspto-grants-2002_04 |