HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-methyl 2-hydroxy-3-phenylpropanoate → (2R)-2-[4-[4-(2-benzyl-1-benzothiophen-3-yl)phenyl]-2-(4-methoxyphenyl)phenoxy]-3-phenylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-methyl 2-hydroxy-3-phenylpropanoate | HCID 5289077 | — |
| Reactant | 4-(2-Benzyl-benzo[b]thiophene-3-yl)-4''-methoxy-[1,1';3',1'']terphenyl-4'-ol | HCID 10553388 | — |
| Product | (2R)-2-[4-[4-(2-benzyl-1-benzothiophen-3-yl)phenyl]-2-(4-methoxyphenyl)phenoxy]-3-phenylpropanoic acid | HCID 9809675 | — |
Reaction Steps
The title compound was prepared from 4-(2-benzyl-benzo[b]thiophene-3-yl)-4″-methoxy-[1,1′;3′,1″]terphenyl-4′-ol, and (S)-(−)-3-phenyllactic acid methyl ester, in substantially the same manner, as described in Example 1, steps g-h, and was obtained as a white solid, mp 82-84° C.; MS m/e 645 (M−H)+;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06369072B2 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-2c915283d76448eb8dd5efd946c4f0d4 |
| Source note | uspto-grants-2002_04 |