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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 840635Generated: October 26, 2026

(S)-methyl 2-hydroxy-3-phenylpropanoate → (2R)-2-[4-[4-(2-benzyl-1-benzothiophen-3-yl)phenyl]-2-(4-methoxyphenyl)phenoxy]-3-phenylpropanoic acid

https://huagongshe.com/reaction/840635

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-methyl 2-hydroxy-3-phenylpropanoateHCID 5289077—
Reactant4-(2-Benzyl-benzo[b]thiophene-3-yl)-4''-methoxy-[1,1';3',1'']terphenyl-4'-olHCID 10553388—
Product(2R)-2-[4-[4-(2-benzyl-1-benzothiophen-3-yl)phenyl]-2-(4-methoxyphenyl)phenoxy]-3-phenylpropanoic acidHCID 9809675—

Reaction Steps

The title compound was prepared from 4-(2-benzyl-benzo[b]thiophene-3-yl)-4″-methoxy-[1,1′;3′,1″]terphenyl-4′-ol, and (S)-(−)-3-phenyllactic acid methyl ester, in substantially the same manner, as described in Example 1, steps g-h, and was obtained as a white solid, mp 82-84° C.; MS m/e 645 (M−H)+;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06369072B2
Source datasetuspto-grants-2002_04
ORD IDord-2c915283d76448eb8dd5efd946c4f0d4
Source noteuspto-grants-2002_04