Hexanoic acid, 2-hydroxy-, ethyl ester → 2-[4''-(2-Benzyl-benzofuran-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-hexanoic acid

HRID 840641Notes

Reaction equation

HRID 840641 reaction equation
[CH2:1]([C:8]1[O:9][C:10]2[CH:31]=[CH:30][CH:29]=[CH:28][C:11]=2[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[C:23]([Br:25])[C:22]([OH:26])=[C:21]([Br:27])[CH:20]=2)=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:32][CH2:33][CH2:34][CH2:35][CH:36](O)[C:37]([O:39]CC)=[O:38]>>[CH2:1]([C:8]1[O:9][C:10]2[CH:31]=[CH:30][CH:29]=[CH:28][C:11]=2[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[C:21]([Br:27])[C:22]([O:26][CH:36]([CH2:35][CH2:34][CH2:33][CH3:32])[C:37]([OH:39])=[O:38])=[C:23]([Br:25])[CH:24]=2)=[CH:15][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 103589Hexanoic acid, 2-hydroxy-, ethyl esterHCID 10506471HCID 10506471, compound

Product 1

HCID 98957912-[4''-(2-Benzyl-benzofuran-3-yl)-3,5-dibromo-biphenyl-4-yloxy]-hexanoic acid

Procedure

The title compound was prepared from 4′-(2-benzyl-benzofuran-3-yl)-3,5-dibromo-biphenyl-4-ol, and ethyl DL-2-hydroxycaproate, in substantially the same manner, as described in Example 1, steps g-h , and was obtained as a white solid, mp 75-76° C.; MS m/e 645 (M−H)+;

Workup

  1. customwas obtained as a white solid, mp 75-76° C.

Sources & evidence

ORD record
ord-b72a65f6b7104227aeeac7163a689bc7
Source dataset
uspto-grants-2002_04
Patent number
US06369072B2

Reaction notes

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