HCID 10506471, compound → HCID 10817657, compound

HRID 840642Notes

Reaction equation

HRID 840642 reaction equation
[CH2:1]([C:8]1[O:9][C:10]2[CH:31]=[CH:30][CH:29]=[CH:28][C:11]=2[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[C:23]([Br:25])[C:22]([OH:26])=[C:21]([Br:27])[CH:20]=2)=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O[C@@H:33]([CH2:41][CH3:42])[C:34]([O:36]C(C)(C)C)=[O:35]>>[CH2:1]([C:8]1[O:9][C:10]2[CH:31]=[CH:30][CH:29]=[CH:28][C:11]=2[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[C:21]([Br:27])[C:22]([O:26][C@@H:33]([CH2:41][CH3:42])[C:34]([OH:36])=[O:35])=[C:23]([Br:25])[CH:24]=2)=[CH:15][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 10506471HCID 10506471, compoundHCID 13237360tert-Butyl (2S)-2-hydroxybutanoate

Product 1

HCID 10817657HCID 10817657, compound

Procedure

The title compound was prepared from 4′-(2-benzyl-benzofuran-3-yl)-3,5-dibromo-biphenyl-4-ol, and tert-butyl (S)-(−)-hydroxybutyrate, in substantially the same manner, as described in Example 1, steps g-h, and was obtained as a white solid, mp 79-80° C.; MS m/e 617 (M−H)+;

Workup

  1. customwas obtained as a white solid, mp 79-80° C.

Sources & evidence

ORD record
ord-b05d04062fd64f49a789cfe3aea1ac16
Source dataset
uspto-grants-2002_04
Patent number
US06369072B2

Reaction notes

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