(S)-methyl 2-hydroxy-3-phenylpropanoate → HCID 10744488, compound

HRID 840644Notes

Reaction equation

HRID 840644 reaction equation
[CH2:1]([C:8]1[S:9][C:10]([CH3:27])=[C:11]([CH3:26])[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=2)=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:29][C:30](=[O:40])[C@H:31]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)O>>[CH2:1]([C:8]1[S:9][C:10]([CH3:27])=[C:11]([CH3:26])[C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]=[CH:21][C:22]([O:25][C@H:31]([CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:30]([OH:40])=[O:29])=[CH:23][CH:24]=2)=[CH:15][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5289077(S)-methyl 2-hydroxy-3-phenylpropanoateHCID 22462573HCID 22462573, compound

Product 1

HCID 10744488HCID 10744488, compound

Procedure

The title compound was prepared from 4′-(2-benzyl-4,5-dimethyl-thiophen-3-yl)-biphenyl-4-ol, and (S)-(−)-3-phenyllactic acid methyl ester, in substantially the same manner, as described in Example 29, and was obtained as an off-white solid, mp 142-144° C.; MS m/e 517 (M−H)+;

Workup

  1. customwas obtained as an off-white solid, mp 142-144° C.

Sources & evidence

ORD record
ord-8357312358de498d8575801c7a8f2a24
Source dataset
uspto-grants-2002_04
Patent number
US06369072B2

Reaction notes

Loading…