HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-1-(bromomethyl)-2-(methanesulfonyl)benzene → 2-(4-Bromo-2-methanesulfonylbenzyl)isoindole-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-1-(bromomethyl)-2-(methanesulfonyl)benzene | HCID 2761074 | — |
| Reactant | Phthalimide potassium salt | HCID 24194345 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Bromo-2-methanesulfonylbenzyl)isoindole-1,3-dione | HCID 22620015 | 49.9% |
Reaction Steps
3.0 g of 4-bromo-1-bromomethyl-2-methanesulfonylbenzene and 2.0 g of potassium phthalimide are stirred at 100° C. for 1 h in 30 ml of anhydrous DMF. The mixture is allowed to cool, diluted with 200 ml of water and the suspension is stirred at RT for 30 minutes. The product is then filtered off and 1.8 g of a colorless solid are obtained, mp 188-190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06369069B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-efa94f2feff94153ab12111dba6eb922 |
| Source note | uspto-grants-2002_04 |