Thionyl Chloride → o-Tolyl-acetyl chloride
Reaction equation
[C:1]1([CH3:11])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8](O)=[O:9].O=S(Cl)[Cl:14]>>[C:1]1([CH3:11])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([Cl:14])=[O:9]Participants
3
Procedure
4.8 g of o-tolylacetic acid are dissolved in 36 ml of SOCl2 and refluxed for 12 h. The volatile constituents are then removed in vacuo and the residue is taken up 3 times in each case in 50 ml of toluene and the volatile constituents are removed in vacuo. 6.6 g of a pale yellow liquid are obtained, which is employed further without purification.
Workup
- temperaturerefluxed for 12 h
- customThe volatile constituents are then removed in vacuo
- customthe volatile constituents are removed in vacuo
Sources & evidence
- ORD record
- ord-f05c5f588cdd47dca7446fca15e700b2
- Source dataset
- uspto-grants-2002_04
- Patent number
- US06369069B1
Reaction notes
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