8-Bromo-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine → HCID 9881885, compound

HRID 84067Notes

Reaction equation

HRID 84067 reaction equation
Cl[C:2]1[C:3]([O:14][CH3:15])=[CH:4][C:5]2[CH2:11][CH2:10][NH:9][CH2:8][CH:7]([CH3:12])[C:6]=2[CH:13]=1.IC1C(OC)=CC2CCNCC(C)C=2C=1.CN1CC(C)C2C=C([Br:46])C(OC)=CC=2CC1.BrC1C(OC)=CC2CCNCC(CC)C=2C=1.ClC1C(OC)=CC2CCNCC(CC)C=2C=1.IC1C(OC)=CC2CCNCC(CC)C=2C=1.COC1C(C(F)(F)F)=CC2C(C)CNCCC=2C=1.COC1C(C(F)(F)C(F)(F)F)=CC2C(C)CNCCC=2C=1>>[Br:46][C:2]1[C:3]([O:14][CH3:15])=[CH:4][C:5]2[CH2:11][CH2:10][NH:9][CH2:8][CH:7]([CH3:12])[C:6]=2[CH:13]=1

Participants

9

Reactant 8

HCID 99940088-Bromo-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 100154147-Methoxy-1-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 100366298-Chloro-7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 100601798-Chloro-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 100643867-iodo-8-methoxy-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 10085262N-Methyl-8-bromo-7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 10314616HCID 10314616, compoundHCID 104254257-Methoxy-1-methyl-8-pentafluoroethyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Product 1

HCID 9881885HCID 9881885, compound

Procedure

8-Chloro-7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; N-Methyl-8-bromo-7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Bromo-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Chloro-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-1-ethyl-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine; 7-Methoxy-1-methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; and 7-Methoxy-1-methyl-8-pentafluoroethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; or a pharmaceutically acceptable salt, solvate or hydrate thereof.

Sources & evidence

ORD record
ord-81c3a7ac9e13442b892792c3cf6d25bb
Source dataset
uspto-grants-2014_09
Patent number
US08846906B2

Reaction notes

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