HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine → 8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 9990808 | — |
| Reactant | 7,8-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | HCID 9991444 | — |
| Reactant | 8-Chloro-7-fluoro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine | HCID 10082477 | — |
| Reactant | 1-Methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 10105208 | — |
| Reactant | 8-Chloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine | HCID 10242203 | — |
| Reactant | 8-Trifluoromethyl-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine | HCID 10243496 | — |
| Reactant | 7,8-Dichloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine | HCID 10263839 | — |
| Reactant | 8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 10331841 | — |
| Reactant | 8-Iodo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine | HCID 10380101 | — |
| Reactant | HCID 10467471 | HCID 10467471 | — |
| Reactant | 8-Iodo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | HCID 11778791 | — |
| Product | 8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine | HCID 10465263 | — |
Reaction Steps
8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Trifluoromethyl-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Trifluoromethyl-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Chloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Bromo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Iodo-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 7,8-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 7,8-Dichloro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 8-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; and 8-Chloro-7-fluoro-1-ethyl-2,3,4,5-tetrahydro-1H-3-benzazepine; or a pharmaceutically acceptable salt, solvate or hydrate thereof.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846906B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5c83002568074a49b063626001e625ef |
| Source note | uspto-grants-2014_09 |