反应详情

A solution of the 1.5 g (6.66 mmol) of N-Boc-2-(cis-1-propenyl)piperdine in 2 mL of ethanol was shaken under 58 psi H2 pressure over 0.3 g Pd/C catalyst overnight, and then the mixture was filtered through Celite and concentrated to give 1.43 g (94%) of the product as a clear colorless oil. No further purification was necessary. 1H NMR (250 MHz) δ4.21-4.17 (br s, 1 H), 3.98-3.92 (br d, I H), 2.79-2.68 (dt, 1 H), 1.67-1.23 (m, 19 H), 0.93-0.88 (t, 3 H); 13C NMR (62.7 MHz) 155.1 (s), 78.9 (s), 50.0 (s), 38.6 (s), 31.8 (s), 28.4 (s), 25.6 (s), 19.1 (s), 18.9 (s), 14.0 (s) ppm.

1. filtrationthe mixture was filtered through Celite
2. concentrationconcentrated