反应详情

To a suspension of the compound (11) (0.35 g, 0.77 mmol) obtained in Example 7 in ethanol (3.5 ml) was added 1N aqueous sodium hydroxide (0.82 ml) under ice-cooling. The reaction mixture was stirred for 30 minutes, concentrated under reduced pressure and extracted with ethyl acetate. The extract was washed with water and concentrated under reduced pressure to yield the objective (12) (0.31 g). Yield 96.9%.

1. temperaturecooling
2. concentrationconcentrated under reduced pressure
3. extractionextracted with ethyl acetate
4. washThe extract was washed with water
5. concentrationconcentrated under reduced pressure