HCID 67498983, compound → HCID 67498962, compound

Participants

Reaction Steps

A solution of trans-N-Boc-2-methyl-6-(ethenyl propionyl)piperidine (2.0 g, 6.70 mmol) in 3 mL of ethanol was shaken under 58 psi of H2 pressure over 0.65 g Pd/C catalyst overnight, and then the mixture was filtered through Celite and concentrated to give 1.8 g (90%) of the product which was homogeneous by TLC analysis. 1H NMR (250 MHz) δ4.16-4.08 (q, 2 H), 3.93-3.83 (m, 2 H), 2.36-2.28 (t, 2 H), 2.04-1.08 (m, 20 H); 13C NMR (62.7 MHz) 155.4 (s), 79.1 (s), 60.3 (s), 51.0 (s), 47.2 (s), 31.9 (s), 29.6 (s), 28.5 (s), 26.9 (s), 25.8 (s), 24.2 (s), 20.5 (s), 14.2 (s), ppm.

Provenance & Evidence