Dichloromethane → HCID 15552067, compound

HRID 840727Notes

Reaction equation

HRID 840727 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](Cl)=[O:10])=[CH:4][CH:3]=1.[CH3:12][O:13][C:14]1[O:18][C:17](=[O:19])[N:16]([C:20]2[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=2)[N:15]=1.C(Cl)Cl>N1C=CC=CC=1>[CH3:12][O:13][C:14]1[O:18][C:17](=[O:19])[N:16]([C:20]2[CH:25]=[CH:24][C:23]([NH:26][C:9](=[O:10])[CH2:8][C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[CH:22][CH:21]=2)[N:15]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 906924-Chlorophenylacetyl chlorideHCID 99207173-(4-Aminophenyl)-5-methoxy-1,3,4-oxadiazol-2(3H)-one

Product 1

HCID 15552067HCID 15552067, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

201 mg of 4-chlorophenylacetyl chloride were added dropwise to a mixture consisting of 200 mg of 5-methoxy-3-(4-aminophenyl)-3H-(1,3,4)oxadiazol-2-one, 20 ml of methylene chloride and 0.1 ml of pyridine cooled in ice, and the mixture was stirred at room temperature for 5 hours. Volatiles were removed in vacuo. The residue was stirred with water and the solid was filtered off with suction and dried at 40° C. in vacuo.

Workup

  1. temperaturecooled in ice
  2. customVolatiles were removed in vacuo
  3. stirringThe residue was stirred with water
  4. filtrationthe solid was filtered off with suction
  5. customdried at 40° C. in vacuo

Sources & evidence

ORD record
ord-a284e5af4a764c20b630b4eeb87d670d
Source dataset
uspto-grants-2002_04
Patent number
US06369088B2

Reaction notes

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