HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-Methoxy-3-(4-dimethylamino-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 5-methoxy-3-(4-amino-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one | HCID 9877857 | — |
| Reactant | Formaldehyde formic acid | HCID 18761834 | — |
| Product | 5-Methoxy-3-(4-dimethylamino-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one | HCID 69969916 | — |
Reaction Steps
The latter compound was obtained by reacting 5-methoxy-3-(4-amino-3-methylphenyl)-3H-(1,3,4)oxadiazol-2-one with paraformaldehyde/formic acid in DMF at room temperature and was purified by column chromatography (silica gel, ethyl acetate:n-heptane=1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06369088B2 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-706d9578ab0547939b3e9a8f4354a098 |
| Source note | uspto-grants-2002_04 |