HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-methoxy-3-(4-amino-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one → 5-Methoxy-3-(4-(4-chlorobenzylamino)-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-methoxy-3-(4-amino-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one | HCID 9877857 | — |
| Reactant | HCID 131723164 | HCID 131723164 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 5-Methoxy-3-(4-(4-chlorobenzylamino)-3-methylphenyl)-3H-(1,3,4)-oxadiazol-2-one | HCID 22620250 | — |
Reaction Steps
The latter compound was obtained by reacting 5-methoxy-3-(4-amino-3-methylphenyl)-3H-(1,3,4)oxadiazol-2-one with 4-chlorobenzaldehyde/sodium borohydride in methanol/methylene chloride at room temperature and was purified by column chromatography (silica gel, ethyl acetate:n-heptane=1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06369088B2 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-06d92ae3f2934f63b0ef1a69ec234efb |
| Source note | uspto-grants-2002_04 |