Sodium Chloride → HCID 9886519, compound

Participants

Reaction Steps

2-(N-Cyclohexanecarbonyl-4-aminophenyl)-5-trifluoromethyl benzimidazole was prepared from the amino, 2-(4-aminophenyl)-5-trifluoromethyl benzimidazole (1.2; see above). The amine (0.239 g, 0.86 mmol) was dissolved in THF:H2O (5 ml, 1:1) followed by K2CO3 (0.1213 g, 0.88 mmol) and cyclohexyl carbonyl chloride (130 μL, 0.95 mmol). The reaction mixture was shaken for 23 h at room temperature. Sodium chloride was added to the reaction and the mixture extracted with EtOAc. The combined organic extracts were washed with water, dried over Na2SO4 and concentrated under vacuum. The resulting solid was purified by preparative TLC (10% MeOH in CH2Cl2).

Provenance & Evidence