Triethylamine → HCID 12042347, compound

Participants

Reaction Steps

1-(2-Chlorobenzyl)-2-n-propylbenzimidazole (150 mg) and triethylamine (61 mg) are dissolved in methylene chloride (3 ml). Methanesulfonyl chloride (70 mg) is added to the mixture solution at room temperature, stirred for 1 hour, and then washed with diluted hydrochloric acid. After it is washed with water, it is dried and the solvent is removed through evaporation under reduced pressure. The solid residue is filtered using ether, and 1-(2-chlorobenzyl)-6-mesylamino-2-n-propylbenzimidazole (124 mg) is obtained. 1H-NMR, (CDCl3—CD3OD, δ): 0.94 (3H, t, J=7.5 Hz), 1.76 (2H, m), 2.71 (2H, t, J=7.5 Hz), 2.81 (3H, s), 5.36 (2H, s), 6.40 (1H, d, J=7.5 Hz), 6.98-7.22 (4H,m), 7.40 (1H, d, J=7.5 Hz), 7.59 (1H, d, J=7.5 Hz).

Provenance & Evidence