Sodium Sulfate → HCID 22620335, compound

Participants

Reaction Steps

Tetrahydrofuran (20 ml) solution of 1-(biphenyl-4-ylmethyl)-6-ethoxycarbonyl-2-methylbenzimidazole (5.30 g) is slowly added to a tetrahydrofuran (20 ml) solution of aluminum lithium hydride (2.17 g). Further, the solution is stirred for one hour at room temperature. By adding tetrahydrofuran (30 ml), the reaction solution is diluted. By adding a saturated sodium sulfate aqueous solution, the aluminum lithium hydride is decomposed, solidified and the tetrahydrofuran layer is separated. The solvent is removed through evaporation. Purification using silica gel column chromatography produced 1-(biphenyl-4-ylmethyl)-6-hydroxymethyl-2-methylbenzimidazole (3.72 g). 1H-NMR (CDCl3, δ): 2.59 (3H, s), 4.78 (2H, s), 5.37 (2H. s), 7.11 (2H, d, J=8.3 Hz), 7.24 (1H, d, J=8.3 Hz), 7.30-7.37 (2H, m), 7.42 (2H, t), 7.51-7.56 (4H, m), 7.70 (1H, d, J=8.2 Hz).

Provenance & Evidence