Hydrochloric Acid → 6-Carboxy-1-(2-Chlorobenzyl)-2-Methylbenzimidazole

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Reaction Steps

Ethanol (80 li) and 10% sodium hydroxide aqueous solution (37 g) are added to 1-(2-chlorobenzyl)-6-ethoxycarbonyl-2-methylbenzimidazole (10.0 g), and the solution is refluxed for 4 hours. After the reaction solution is cooled, its acidity is adjusted to pH 6 with 10% hydrochloric acid. The sediment is gathered, washed with water, dried under reduced pressure, and thus, 6-carboxy-1-(2-chlorobenzyl)-2-methylbenzimidazole (8.30 g) is obtained.

Provenance & Evidence