Lithium Hydroxide → HCID 178427487, compound

Participants

Reaction Steps

A solution of the compound of Example 11 (185 mg, 0.32 mmol) in THF (2 mL) was treated with 2 N LiOH (0.32 mL, 0.64 mmol). The mixture was stirred at room temperature for two and one-half hours. The organic solvent was evaporated in vacuo. The aqueous layer was extracted with EtOAc to remove organic impurities and acidified to pH 2-3 with 2N aq HCl at 0° C. The acidified aqueous layer was extracted with EtOAc and the organic layer was dried over Na2SO4 and evaporated to give the title compound as a white solid (149 mg).

Provenance & Evidence