Phenylmethanesulfonyl chloride → HCID 178501526, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound of Example 16 (0.48 mmol) and DIEA in CH2Cl2 (2 mL) at −78° C., was added α-toluenesulfonyl chloride (110 mg, 0.57 mmol). The mixture was stirred at −78° C. for three hours and evaporated in vacuo. The residue was dissolved in CH2Cl2 and H2O. The organic layer was washed with sat. NaHCO3, sat. NaCl, dried over Na2SO4 and evaporated to give the title compound as a solid (50% yield).

Provenance & Evidence