2,6-Dimethoxybenzylamine → HCID 178491373, compound

HRID 840847Notes

Reaction equation

FC1C(O[C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[C:14]3=[N:21][NH:22][C:23]2[CH:28]=[CH:27][C:26]([S:29](=[O:32])(=[O:31])[NH2:30])=[CH:25][CH:24]=2)=[O:10])=C(F)C(F)=C(F)C=1F.[CH3:37][O:38][C:39]1[CH:46]=[CH:45][CH:44]=[C:43]([O:47][CH3:48])[C:40]=1[CH2:41][NH2:42]>>[CH3:48][O:47][C:43]1[CH:44]=[CH:45][CH:46]=[C:39]([O:38][CH3:37])[C:40]=1[CH2:41][NH:42][C:9]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[C:14]2=[N:21][NH:22][C:23]1[CH:28]=[CH:27][C:26]([S:29](=[O:31])(=[O:32])[NH2:30])=[CH:25][CH:24]=1)=[O:10]

Participants

Reactant 2

HCID 28008722,6-Dimethoxybenzylamine

HCID 178514750HCID 178514750, compound

Product 1

HCID 178491373HCID 178491373, compound

Procedure

The title compound was prepared from 2-oxo-3[(4-sulfamoyl-phenyl)-hydrazono]-2,3-dihydro-1H-indole-5-carboxylic acid pentafluorophenyl ester and 2,6-dimethoxybenzylamine according to Procedure K: mp>250° C.; 1H NMR (DMSO-d6): δ3.76 (s, 6H), 4.43 (d, J=4.2 Hz, 2H), 6.65 (d, J=8.4 Hz, 2H), 6.91 (d, J=8.2 Hz, 1H), 7.23 (s, 2H), 7.25 (d, J=8.2 Hz, 1H), 7.56 (d, J=8.6 Hz, 2H), 7.79 (m, 3H), 8.07 (s, 1H), 8.13 (br s, 1H), 11.27 (s, 1H), 12.76 (s, 1H); APCI−MS m/z 532 (M+Na)+; Anal. Calcd for C24H23N5O6S.1/2H2O: C, 55.59; H, 4.67; N, 13.51; S, 6.18. Found: C, 55.69; H, 4.64; N, 13.61; S, 6.09.

Sources & evidence

ORD record: ord-822b6f03c2f448d8858543c173d743a0
Source dataset: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06369086B1

Reaction notes

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