HCID 21956323, compound → HCID 178514775, compound

HRID 840857Notes

Reaction equation

HRID 840857 reaction equation
O[CH:2]=[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:12].[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][S:21]([NH2:24])(=[O:23])=[O:22])=[CH:16][CH:15]=1>>[O:12]=[C:4]1[C:3](=[CH:2][NH:13][C:14]2[CH:19]=[CH:18][C:17]([NH:20][S:21]([NH2:24])(=[O:23])=[O:22])=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5]1

Participants

3

Reactant 2

HCID 21956323HCID 21956323, compoundHCID 1784187413-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 178514775HCID 178514775, compoundYield 52%

Procedure

The title compound was prepared from 3-hydroxymethylene-1,3-dihydro-indol-2-one and 4-aminophenylsulfamide according to Procedure J in 52% yield: 1H NMR (DMSO-d6): δ6.85 (d, J=7.5 Hz, 1H), 6.93 (t, J=7.5 Hz, 1H), 7.01 (t, J=7.5 Hz, 1H), 7.08 (s, 2H), 7.21 (d, J=8.8 Hz, 2H), 7.36 (d, J=8.8 Hz, 2H), 7.57 (d, J=7.5 Hz, 1H), 8.53 (d, J=12.7 Hz, 1H), 9.38 (s, 1H), 10.48 (s, 1H), 10.70 (d, J=12.7 Hz, 1H): APCI−MS m/z 329 (M−H)−. Anal. Calcd for C15H14N4O3S: C, 54.54, H, 4.27; N, 16.96; S, 9.71. Found C, 54.48, H, 4.30; N, 16.90; S, 9.63.

Sources & evidence

ORD record
ord-13b0b39396ca48bc93d70ff5cb311667
Source dataset
uspto-grants-2002_04
Patent number
US06369086B1

Reaction notes

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