HCID 13286111, compound → HCID 178458104, compound

HRID 840875Notes

Reaction equation

HRID 840875 reaction equation
C(O[CH:4]=[C:5]1[C:16]2[C:8](=[CH:9][CH:10]=[C:11]3[C:15]=2[S:14][CH:13]=[N:12]3)[NH:7][C:6]1=[O:17])C.[CH2:18]([NH:21][S:22]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][CH:27]=1)(=[O:24])=[O:23])[CH:19]=[CH2:20]>>[CH2:18]([NH:21][S:22]([CH2:25][C:26]1[CH:27]=[CH:28][C:29]([NH:32][CH:4]=[C:5]2[C:16]3[C:8](=[CH:9][CH:10]=[C:11]4[C:15]=3[S:14][CH:13]=[N:12]4)[NH:7][C:6]2=[O:17])=[CH:30][CH:31]=1)(=[O:24])=[O:23])[CH:19]=[CH2:20]

Participants

3

Reactant 2

HCID 13286111HCID 13286111, compoundHCID 539908078-[Ethoxymethylidene]-6H-[1,3]thiazolo[5,4-e]indol-7-one

Product 1

HCID 178458104HCID 178458104, compoundYield 26%

Procedure

The title compound was prepared in 26% yield from 8-ethoxymethylene-6,8-dihydro-1-thia-3,6-diaza-as-indacen-7-one and N-allyl-4-aminophenylmethane sulfonamide according to Procedure J: 1H NMR (DMSO-d6): δ11.1 (d, 1H), 10.9 (s, 1H), 9.3 (s, 1H), 8.1 (d, 1H), 7.8 (d, 1H), 7.5 (q, 4H), 7.3 (t, 1H), 7.1 (d, 1H), 5.8 (m, 1H), 5.2 (d, 1H), 5.1 (d, 1H), 4.4 (s, 2H), 3.6 (t, 2H); APCI−MS m/z 427 (M+H)+.

Sources & evidence

ORD record
ord-50c608c142e8442f9aae291f7eb00f8b
Source dataset
uspto-grants-2002_04
Patent number
US06369086B1

Reaction notes

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