4-Amino-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamide → HCID 178516999, compound

HRID 840878Notes

Reaction equation

HRID 840878 reaction equation
C(O[CH:4]=[C:5]1[C:16]2[C:8](=[CH:9][CH:10]=[C:11]3[C:15]=2[S:14][CH:13]=[N:12]3)[NH:7][C:6]1=[O:17])C.[F:18][C:19]([F:38])([F:37])[C:20]1[CH:21]=[C:22]([NH:26][S:27]([C:30]2[CH:35]=[CH:34][C:33]([NH2:36])=[CH:32][CH:31]=2)(=[O:29])=[O:28])[CH:23]=[CH:24][CH:25]=1>>[O:17]=[C:6]1[C:5](=[CH:4][NH:36][C:33]2[CH:34]=[CH:35][C:30]([S:27]([NH:26][C:22]3[CH:23]=[CH:24][CH:25]=[C:20]([C:19]([F:38])([F:18])[F:37])[CH:21]=3)(=[O:29])=[O:28])=[CH:31][CH:32]=2)[C:16]2[C:8](=[CH:9][CH:10]=[C:11]3[C:15]=2[S:14][CH:13]=[N:12]3)[NH:7]1

Participants

3

Reactant 2

HCID 2327654-Amino-N-[3-(trifluoromethyl)phenyl]benzene-1-sulfonamideHCID 539908078-[Ethoxymethylidene]-6H-[1,3]thiazolo[5,4-e]indol-7-one

Product 1

HCID 178516999HCID 178516999, compoundYield 29%

Procedure

The title compound was prepared in 29% yield from 8-ethoxymethylene-6,8-dihydro-1-thia-3,6-diaza-as-indacen-7-one and N-(3-trifluoromethylphenyl)-4-aminobenzenesulfonamide according to Procedure J: 1H NMR (DMSO-d6): δ11.2 (d, 1H), 10.9 (s, 1H), 10.7 (s, 1H), 9.3 (s, 1H), 8.1 (d, 1H), 7.8 (m, 3H), 7.5 (m, 4H), 7.1 (d, 1H); APCI−MS m/z 515 (M−H)−.

Sources & evidence

ORD record
ord-36dbc7cc0ac94cf99b46539fc004801c
Source dataset
uspto-grants-2002_04
Patent number
US06369086B1

Reaction notes

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