Sulfamethizole → HCID 178434114, compound

HRID 840880Notes

Reaction equation

HRID 840880 reaction equation
C(O[CH:4]=[C:5]1[C:16]2[C:8](=[CH:9][CH:10]=[C:11]3[C:15]=2[S:14][CH:13]=[N:12]3)[NH:7][C:6]1=[O:17])C.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([S:25]([NH:28][C:29]2[S:30][C:31]([CH3:34])=[N:32][N:33]=2)(=[O:27])=[O:26])=[CH:21][CH:20]=1>>[CH3:34][C:31]1[S:30][C:29]([NH:28][S:25]([C:22]2[CH:23]=[CH:24][C:19]([NH:18][CH:4]=[C:5]3[C:16]4[C:8](=[CH:9][CH:10]=[C:11]5[C:15]=4[S:14][CH:13]=[N:12]5)[NH:7][C:6]3=[O:17])=[CH:20][CH:21]=2)(=[O:27])=[O:26])=[N:33][N:32]=1

Participants

3

Reactant 2

HCID 5328SulfamethizoleHCID 539908078-[Ethoxymethylidene]-6H-[1,3]thiazolo[5,4-e]indol-7-one

Product 1

HCID 178434114HCID 178434114, compoundYield 36%

Procedure

The title compound was prepared in 36% yield from 8-ethoxymethylene-6,8-dihydro-1-thia-3,6-diaza-as-indacen-7-one and 4-amino-N-(5-methyl[1,3,4]thiadiazol-2-yl)-benzenesulfonamide according to Procedure J: 1H NMR (DMSO-d6): δ11.2 (d, 1H), 10.9 (s, 1H), 9.3 (s, 1H), 8.1 (d, 1H), 7.8 (m, 3H), 7.6 (d, 2H), 7.1 (d, 1H); ESI−MS m/z469 (M−H)−.

Sources & evidence

ORD record
ord-607693746a204202a60754596d1be949
Source dataset
uspto-grants-2002_04
Patent number
US06369086B1

Reaction notes

Loading…