1H-Indazol-6-amine → HCID 21956186, compound

HRID 840896Notes

Reaction equation

HRID 840896 reaction equation
O[CH:2]=[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]1=[O:12].[NH2:13][C:14]1[CH:22]=[C:21]2[C:17]([CH:18]=[N:19][NH:20]2)=[CH:16][CH:15]=1>>[NH:20]1[C:21]2[C:17](=[CH:16][CH:15]=[C:14]([N:13]=[C:2]=[C:3]3[C:11]4[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=4)[NH:5][C:4]3=[O:12])[CH:22]=2)[CH:18]=[N:19]1

Participants

3

Reactant 2

HCID 814231H-Indazol-6-amineHCID 1784187413-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 21956186HCID 21956186, compoundYield 79%

Procedure

The title compound was prepared in 79% yield from 3-hydroxymethylene-1,3-dihydro-indol-2-one and 6-aminoindazole according to Procedure J: 1H NMR (DMSO-d6): δ13.02 (s, 1H), 10.86 (d, 1H), 10.51 (s, 1H), 8.7 (d, 1H), 8.0 (s, 1H), 7.74 (d, 1H), 7.63 (d, 1H), 7.51 (s, 1H), 7.15 (dd, 1H), 7.02 (m, 1H), 6.94 (m, 1H), 6.85 (d, 1H); ESI−MS m/z 275 (M−H)−.

Sources & evidence

ORD record
ord-a6d6af73377941fa84f14defda30f585
Source dataset
uspto-grants-2002_04
Patent number
US06369086B1

Reaction notes

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