Ammonia → HCID 15549909, compound

Participants

Reaction Conditions

Reaction Steps

The ethyl 1-(4-methylphenylsulfonyl)-2,3-dihydro-1H-benz[b]azepine-4-carboxylate (0.63 g, 1.70 mmol) synthesized in Reference Example 4 was added to a mixture of trifluoroacetic acid (10 ml), methanesulfonic acid (0.30 g) and thioanisole (1.0 ml) which had been cooled to 0° C., and the resulting mixture was stirred at room temperature for 3.5 hours. The reaction mixture was poured into cooled aqueous ammonia and extracted twice with ethyl acetate, and the extract solution was washed twice with a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent; ethyl acetate:n-hexane=5:95) to obtain 0.32 g of ethyl 2,3-dihydro-1H-benz [b]azepine-4-carboxylate.

Provenance & Evidence