反应详情

温度

70 °C

5-Phenyl-3-methylpentanoic acid (0.10 g, 0.52 mmol) was added to polyphosphoric acid (7 g), and the resulting mixture was stirred at 70° C. for 1 hour. Water was added to the reaction mixture, followed by extraction with ethyl acetate, and the extract solution was washed with water, a saturated aqueous sodium hydrogencarbonate solution and a saturated aqueous sodium chloride solution, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 0.07 g of 7-methyl-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one.

1. extractionfollowed by extraction with ethyl acetate
2. washthe extract solution was washed with water
3. dry with materiala saturated aqueous sodium hydrogencarbonate solution and a saturated aqueous sodium chloride solution, and then dried over anhydrous magnesium sulfate
4. distillationThe solvent was distilled off under reduced pressure