HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 3'-O-(t-butyldiphenylsilyl)thymidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| Reactant | 1-[5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione | HCID 627554 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3'-O-(t-butyldiphenylsilyl)thymidine | HCID 11016319 | — |
Reaction Steps
5′-O-Dimethoxytritylthymidine is silylated with 1 equivalent of t-butyldiphenylsilyl chloride (TBDPSCl) and 2 equivalents of imidazole in DMF solvent at room temperature. The 5′-protecting group is removed by treating with 3% dichloracetic acid in CH2Cl2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06369209B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-00cdc9f50b0d4afba6f0d1b742dbe854 |
| Source note | uspto-grants-2002_04 |