Hydrochloric Acid → N-Octadecanoylacrylamide

Participants

Reaction Steps

Into a 250 -mL-capacity conical flask equipped with an anhydrous calcium chloride (CaCl2) guard tube, 15.1 g 1-octadecanoyl chloride [CH3—(CH2)16—COCl] (0.005 M). 3.5 g acrylamide (CH2═CH—CO—NH2) (0.05 M), and 50 ml acetone were placed to obtained a clear solution. The solution was stirred with a magnetic needle at room temperature. Anhydrous zinc chloride (ZnCl2), 6.5 g (0.05 M), was added and the reaction mixture was stirred at room temperature. After 5-10 min of stirring, vigorous evolution of hydrogen chloride took place which ceased after about 5 min. The temperature of reaction mixture was increased to 40-50° C. It was then cooled to room temperature and poured into 500 ml cold distilled water. A white product precipitated. The product was isolated and purified by reprecipitation from acetone into cold water. The purified product was dried in a vacuum desiccator.

Provenance & Evidence