Chloride → HCID 131723177, compound

Participants

Reaction Steps

The compound was prepared according to the procedure described in Example 1 for the synthesis of (XIX), prepared starting from 6 g of the chloride of acetylsalicylic acid, 4.6 ml of TEA and 1.9 g of 1.6-hexandiol. The product was purified by flash chromatography utilizing an eluent mix constituted by ethylether/hexane 7:3 (v/v). The intermediate fractions were collected, the solvent was evaporated under reduced pressure and a solid residue was obtained which, triturated with isopropyl ether, produced 1 g of 1.6-hexandiol bis-acetylsalicylate (II) with m.p.=96° C.

Provenance & Evidence