HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178500813, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)3-{[2-Benzyloxycarbonylamino-3-(1-trityl-1H-imidazol-4-yl)-propionyl]-tert-butoxycarbonylmethyl-amino}-propionic acid methyl ester | HCID 69904971 | — |
| Product | HCID 178500813 | HCID 178500813 | 91% |
Reaction Steps
The compound from Step 2 (1.38 g, 1.9 mmol) was treated with 95% aqueous trifluoroacetic acid for 1.5 hours. The solvent was reduced to a few milliliters, and pipetted into 200 mL of ether/hexanes. The product was allowed to precipitate overnight at −40° C. The solid was collected, rinsed and dried; 0.75 g (91% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06369034B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-acc4496bc6a245be8284a4d3002f006f |
| Source note | uspto-grants-2002_04 |