反应详情

A mixture of 2-amino-4-methylbenzoic acid (15.0 g) and concentrated sulphuric acid (20 ml) was heated under reflux with methanol for 18 hours. After removal of the solvent the residue was dissolved in dichloromethane, basified with sodium carbonate solution and the organic phase was washed with water, dried (anhydrous magnesium sulphate) and the solvent evaporated to give methyl 2-amino-4-methylbenzoate, m.p. 41-43° C.

1. temperaturewas heated
2. customAfter removal of the solvent the residue
3. dissolutionwas dissolved in dichloromethane
4. washthe organic phase was washed with water
5. dry with materialdried (anhydrous magnesium sulphate)
6. customthe solvent evaporated