4-Bromothiophenol → HCID 22621246, compound

Participants

Reaction Steps

Sodium (0.269 g) was added to ethanol (20 ml) and the resultant solution was allowed to cool to ambient temperature then 4-bromothiophenol (2.21 g) was added. The mixture was stirred for 5 minutes then 5-chloro-2-nitroaniline (2 g) was added. The mixture was then heated under reflux under argon for 3 hours then allowed to cool down. The resultant solid was collected by filtration , washed with ethanol then dried to give the title compound (236 g) as a solid. NMR: 6.3 8 (dd, 1H), 6.65 (m, 1H), 7.42 (m, 4H), 7.7 (m, 2H), 7.9 (d, 1H); MS: 327 (M+H)+.

Provenance & Evidence