Acetonitrile → 5-(4-(isopropylsulfonyl)phenyl)-3-(1-phenyl-1H-1,2,3-triazol-4-yl)pyrazin-2-amine

Participants

Reaction Steps

To a solution of tert-butyl N-tert-butoxycarbonyl-N-[5-(4-isopropylsulfonylphenyl)-3-(1-phenyltriazol-4-yl)pyrazin-2-yl]carbamate (193 mg, 0.3109 mmol) in DCM (3 mL) was added TFA (1 mL). The reaction mixture was stirred at ambient temperature for 1 h. The reaction mixture was concentrated in vacuo, more DCM was added and concentrated in vacuo to leave a yellow solid. The solid was sonicated in a small amount of MeCN and solid collected by filtration and dried by suction to provide the sub-titled product 5-(4-(isopropylsulfonyl)phenyl)-3-(1-phenyl-1H-1,2,3-triazol-4-yl)pyrazin-2-amine Compound I-1 as a pale yellow solid (105 mg, 80%). 1H NMR (400.0 MHz, DMSO-d6) δ 9.66 (s, 1H), 8.85 (s, 1H), 8.46 (d, 2H), 8.12 (d, 2H), 7.91 (d, 2H), 7.74 (br s, 2H), 7.67 (t, 2H), 7.58 (t, 1H), 3.47 (quintet, 1H) and 1.19 (d, 6H) ppm; LC/MS m/z 421.1 [M+H]+.

Provenance & Evidence