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Chloroform → (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-N-octyl-methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroform | HCID 6212 | — |
| 反応物 | Octylamine | HCID 8143 | — |
| 反応物 | HCID 12138182 | HCID 12138182 | — |
| 反応物 | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl-methanesulfonyl)-piperidine-4-carboxylic acid methyl ester | HCID 12138183 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-N-octyl-methanesulfonamide | HCID 12138188 | 81% |
反応手順
(1-Ethyl-2,2-dimethyl-1,2-dihydroquinol-4-yl)-N-octyl-methanesulfonamide (12) is prepared similarly to compound (10) using compound (9) with n-octylamine. The product is isolated by column chromatography on silica gel with a gradient running from chloroform to ethanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846924B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-f81aef51316c4d8dbc9e61891d4435fd |
| 出典メモ | uspto-grants-2014_09 |