反应详情

The methyl(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoate (R)-(−)-mandelate (30) (113.0 gm) was taken in water (10.0 vol, 1.13 Ltr) and the suspension was stirred for 10-15 minutes. The suspension was further basified by using a 10% Na2CO3 solution (1.0 vol, 113.0 ml) until the pH of the reaction mixture reached 8-9. The product was extracted in ethyl acetate (2×10.0 vol, 2×1.13 Ltr). The combined ethyl acetate layers were further washed with water (2×10.0 vol, 2×1.13 Ltr). The product was isolated as a pale yellow oil by complete distillation of the ethyl acetate under reduced pressure at 45-50° C.

1. extractionThe product was extracted in ethyl acetate (2×10.0 vol, 2×1.13 Ltr)
2. washThe combined ethyl acetate layers were further washed with water (2×10.0 vol, 2×1.13 Ltr)
3. customThe product was isolated as a pale yellow oil by complete distillation of the ethyl acetate under reduced pressure at 45-50° C.