HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Amantadine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Memantine Hydrochloride | HCID 181458 | — |
| Product | Amantadine | HCID 2130 | 5% |
Reaction Steps
In a manner similar to the preparation of the compound of formula DC in Example 13, the compound of formula SA was prepared except that the compound of formula EC was used in place of the compound of formula DB and memantine hydrochloride (i.e., the hydrochloride of 1-amine-3,5-dimethyl-adamantane, Sigma-Aldrich) was used in place of 1-adamantylamine (yield 5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846929B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-f0a521b1817848ec8f98d8414288354d |
| Source note | uspto-grants-2014_09 |