Ethanol → [4-(3,5-Di-tert-butyl-4-methoxy-phenylethynyl)-phenyl]-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Ethanol	HCID 702	—
Reactant	Water	HCID 962	—
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	[4-(3,5-Di-tert-butyl-4-methoxy-phenylethynyl)-phenyl]-acetic acid methyl ester	HCID 69549030	—
Solvent	Acetonitrile	HCID 6342	—
Product	[4-(3,5-Di-tert-butyl-4-methoxy-phenylethynyl)-phenyl]-acetic acid	HCID 10134274	—

Reaction Steps

Following General Procedure I and using [4-(3,5-di-tert-butyl-4-methoxy-phenylethynyl)-phenyl]-acetic acid methyl ester (Compound 142, 0.114 g, 0.29 mmol), 5M aqueous sodium hydroxide solution (2 mL) and ethanol (4 mL), followed by preparative reverse phase HPLC using 10% water in acetonitrile as the mobile phase, the title compound was obtained as a white solid (0.097 g, 88%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06369261B1
Source dataset	uspto-grants-2002_04
ORD ID	ord-3aa6d3e24d4c4ab59f23a02c15fbb9fc
Source note	uspto-grants-2002_04