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HRID841849

反应详情

EQUATION

反应方程式

HRID 841849 的结构方程式

REACTANTS

反应物

2
结构：C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C
HCID5991

17alpha-Ethinylestradiol

C20H24O2

4 次

结构：C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC
HCID6540478

Norgestimate

C23H31NO3

3 次

PRODUCTS

生成物

1
结构：C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C.C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC
HCID9571023

未命名化合物

PROCEDURE

实验过程

PEG with molecular weight in the range of 1,000 to 20,000, preferably PEG 6000-8000, is micronized by Jet mill together with ethinyl estradiol at the ratio of ethinyl estradiol to PEG 1:1 to 1:60, , preferably 1:30 to 1:42. Adjust Jet mill to produce particle size of 1-100 μm, preferably 5-10 μm. Micronized norgestimate powder is electrically charged, and deposited on the substrate surface. Micronized PEG 6000/ethinyl estradiol mixture is electrically charged, and deposited on top of norgestimate. Surface deposited PEG is place under Infrared lamp until melt. PEG will form a coating film while cooling. In the similar manner, deposit PEG ethinyl estradiol mixture and coat bottom side and rest of the tablet surface. Adjust the charge of the substrate so that total of 250 μg of norgestimate and 35 μg of ethinyl estradiol are deposited on the substrate (placebo tablet) surface.

WORKUP

后处理

  1. customAdjust Jet mill to produce particle size of 1-100 μm, preferably 5-10 μm
  2. customPEG will form a coating film
  3. temperaturewhile cooling