Ammonium Chloride → HCID 178452345, compound

HRID 841880Notes

Reaction equation

HRID 841880 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12](OC)=[N:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl-:17].[NH4+:18]>C(O)C>[ClH:17].[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12](=[NH:18])[NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 22617758HCID 22617758, compound

Product 1

HCID 178452345HCID 178452345, compoundYield 92.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-(tert-butoxycarbonyl)-2,3,6,7-tetrahydro-5-methoxy-(1H)-1,4-diazepine (170 mg, 0.75 mmol) and ammonium chloride (40.1 mg, 0.75 mmol) in 2.0 mL of anhydrous ethanol was refluxed for 3 h. The solvent was then removed in vacuo and residue was triturated with 3×10 mL of ether to give 174 mg of 1-(tert-butoxycarbonyl)-hexahydro-5-imino-(1H)-1,4-diazepine hydrochloride as a light yellow solid.

Workup

  1. temperaturewas refluxed for 3 h
  2. customThe solvent was then removed in vacuo and residue
  3. customwas triturated with 3×10 mL of ether

Sources & evidence

ORD record
ord-468ddbf8bc854550924365030c56009f
Source dataset
uspto-grants-2002_04
Patent number
US06372733B1

Reaction notes

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