HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Acetate → 1-(2-Methyl-1,3-dioxolan-2-YL)cyclopropane-1-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | [1-(2-Methyl-1,3-dioxolan-2-yl)cyclopropyl]methanol | HCID 22042312 | — |
| Reactant | HCID 178418287 | HCID 178418287 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(2-Methyl-1,3-dioxolan-2-YL)cyclopropane-1-carbaldehyde | HCID 14375557 | 82% |
Reaction Steps
10 g of 96 in 500 ml of methylene chloride is dissolved, and 3.7 g of sodium acetate (anhydrous) and 19.3 g of pyridinium chlorochromate are added. It is now stirred for 2 hours under argon. It is diluted with 1 l of diethyl ether and then filtered on Celite. Concentration by evaporation of the solvent followed by chromatographic purification on silica gel with ethyl acetate/hexane yields 8.1 g of 1-(2-methyl-1,3-dioxolan-2-yl)cyclopropanecarbaldehyde 97 as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06372731B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-9fce5c44da4b40718ded438eca8ad60a |
| Source note | uspto-grants-2002_04 |