Sodium hydride → HCID 73986464, compound

Participants

Reaction Steps

The product from step A (50 mg) was treated with 1.2 equivalents of NaH in DMF solution with cooling for 1 hr. 2-Thienylsulfonyl chloride (34 mg, 1.3 equivaltents) was added cautiously. After 18 hrs. at ambient temperature and finally at 70° C., the mixture was poured onto ice and the precipitate was filtered. The title compound was filtered and washed with ether. HPLC ‘System 1’ (Ex. 1) showed 80% purity; structure confirmed by mass spec [m\e 497 (M+1)].

Provenance & Evidence