2-Dimethylaminopyridine → HCID 73986452, compound

Participants

Reaction Steps

5-Benzyloxy-3-(2,4-dioxo-thiazolidin-5-ylidene-methyl)-indole (Example 1, Step A; 10 mg) was dissolved in pyridine (1.5 mL) and 3,4-dichlorobenzoyl chloride (35 mg) and a trace of dimethylaminopyridine were added. The mixture was stirred at 50-60° for 18 hrs until the reaction was determined to be complete by TLC. Volatiles were removed under reduced pressure and the residue was washed with water and ether; 10 mg; consistent nmr and ms (m\e 525 (M+1); greater than 95% by HPLC.

Provenance & Evidence